Enclomiphene

Enclomiphene is an oral medication that stimulates the body to produce more of its own testosterone. It belongs to a class of medications known as Selective Estrogen Receptor Modulators (SERMs).

Unlike Testosterone Replacement Therapy (TRT), Enclomiphene is not testosterone. Instead, it enhances your body’s natural hormone signaling pathways to raise testosterone levels internally.

Enclomiphene works by blocking estrogen receptors in the hypothalamus and pituitary gland. This “tricks” the brain into thinking estrogen levels are low, causing it to produce more signaling hormones:

• Luteinizing Hormone (LH): Stimulates the testes to produce testosterone.
• Follicle-Stimulating Hormone (FSH): Supports sperm production and fertility.

By raising both LH and FSH, Enclomiphene boosts natural testosterone while helping preserve or improve fertility.

Clomid (Clomiphene Citrate) contains two isomers:

• Enclomiphene: The active, anti-estrogenic isomer that boosts testosterone.
• Zuclomiphene: A more estrogenic isomer with a long half-life.

Enclomiphene therapy isolates only the active enclomiphene portion, avoiding zuclomiphene-related issues such as:

• Mood swings
• Hot flashes
• Vision disturbances

This is why many providers — including Nu Health Wellness — prefer enclomiphene over traditional Clomid for men.

Reported benefits include:

• Boosts natural testosterone without shutting down your own production
• Preserves fertility by increasing FSH and LH
• Improves low T symptoms such as fatigue, low mood, and low libido
• Daily oral pill — no injections required

Enclomiphene is commonly considered for:

• Men with low testosterone who want to preserve fertility
• Men with symptoms such as fatigue, low mood, or low libido
• Men who prefer to avoid TRT injections
• Athletes seeking a natural testosterone boost

• TRT: Provides external testosterone, which suppresses LH/FSH, shutting down your natural testosterone production and often leading to infertility.
• Enclomiphene: Stimulates internal testosterone production by keeping LH and FSH signaling active. Helps maintain fertility and testicular function.

Enclomiphene generally has fewer side effects than Clomid, but possible effects include:

• Headache
• Nausea or mild GI discomfort
• Mood changes or irritability
• Visual changes (rare but monitored)

Rare but more serious risks may include blood clots, especially in those with cardiovascular risk factors. Medical supervision is essential.

Yes. Enclomiphene is widely used in Post Cycle Therapy to help restart natural testosterone production after anabolic steroid cycles, restoring LH and FSH levels.

Enclomiphene itself (previously developed as “Androxal”) is not FDA-approved.

• Clomid — which contains enclomiphene — is FDA-approved for female infertility.
• Enclomiphene is commonly prescribed off-label by clinics as a compounded medication.
• Compounded drugs are not individually FDA-approved for safety or effectiveness.

This FAQ is for informational purposes only and does not constitute medical advice. Always consult with a licensed provider to determine whether Enclomiphene is appropriate and safe for you.