Semaglutide

Semaglutide is a GLP-1 receptor agonist that mimics a natural hormone called Glucagon-Like Peptide-1 (GLP-1). It supports weight loss in three main ways:

• Appetite control: Acts on brain centers that regulate hunger, reducing appetite and cravings.
• Slowed digestion: Slows gastric emptying so you feel full longer after meals.
• Blood sugar regulation: Helps the pancreas release insulin appropriately, improving metabolic health.

• Wegovy®: FDA-approved specifically for chronic weight management.
• Ozempic® (injection) & Rybelsus® (oral): FDA-approved for Type 2 diabetes and cardiovascular risk reduction, often used off-label for weight loss.

Typical candidates are adults who:

• Have a BMI ≥ 30 (obesity), or
• Have a BMI ≥ 27 (overweight) with at least one weight-related condition (high blood pressure, high cholesterol, Type 2 diabetes, etc.).

Semaglutide is used together with a reduced-calorie diet, increased physical activity, and lifestyle coaching.

The most common side effects are gastrointestinal, especially at the beginning or when the dose increases.

Nausea

• “Start low, go slow” with dose increases.
• Eat smaller, more frequent meals.
• Avoid greasy, fried, spicy, or very rich foods.
• Sip clear liquids or ginger tea between meals (not with meals).

Constipation

• Increase water and fiber intake.
• Light daily movement and exercise.
• Consider OTC stool softeners or magnesium if your provider approves.

Vomiting / Diarrhea

• Use bland foods (BRAT: bananas, rice, applesauce, toast).
• Stay hydrated with water and electrolyte drinks to prevent dehydration.

Many users report a reduced desire for alcohol, nicotine, or other compulsive behaviors. This is not an approved indication, but GLP-1 medications act on brain reward pathways, which may lower cravings.

If you drink alcohol, be cautious: slowed digestion can intensify alcohol’s effects. Always drink in moderation and follow your provider’s guidance.

These are non-medical, social media terms describing the effects of rapid weight loss, not a direct drug toxicity. As body fat decreases, fat pads in the face and other areas can shrink, sometimes leading to a more hollow look.

Helpful strategies:

• Lose weight gradually when possible.
• Prioritize adequate protein intake.
• Include resistance training to preserve lean muscle mass and support body composition.

In clinical trials, many patients lost around 15–20% of their total body weight over about one year, when combined with diet and exercise. Individual results vary based on adherence, metabolism, and lifestyle.

Semaglutide is usually given as a once-weekly subcutaneous injection (under the skin) in the abdomen, thigh, or upper arm.

The dose is gradually increased over weeks to months under medical supervision to minimize GI side effects.

Yes. A responsible Semaglutide program should include:

• Initial consultation and health assessment
• Personalized dosing and treatment plan
• Ongoing follow-ups to monitor side effects, labs, and progress
• Support with nutrition, movement, and behavior change

Frequently reported side effects include:

• Nausea
• Diarrhea
• Vomiting
• Constipation
• Abdominal (stomach) pain
• Headache and fatigue

Key safety warnings include:

• Thyroid C-cell tumors (MTC): Boxed Warning based on animal studies. Do not use if you have a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Pancreatitis: Risk of inflammation of the pancreas; seek urgent care for severe, persistent abdominal pain.
• Gallbladder problems: Including gallstones, which may present with right-upper-quadrant pain, fever, or jaundice.
• Kidney injury: Severe vomiting or diarrhea can cause dehydration, potentially leading to acute kidney injury.
• Pregnancy: Not recommended during pregnancy; typically discontinued at least 2 months before trying to conceive.

The FDA has warned about unapproved compounded Semaglutide products. Some use semaglutide sodium or semaglutide acetate, which are not the same as the active ingredient in FDA-approved medications (Wegovy, Ozempic, Rybelsus).

These products may not be proven safe or effective and can vary in potency and purity. It is critical to obtain Semaglutide only through a licensed provider and a reputable pharmacy.

This FAQ is for educational purposes only and does not replace a consultation with a licensed healthcare provider. Always discuss risks, benefits, and alternatives with your doctor before starting or changing any medication, including Semaglutide or other GLP-1 therapies.